Screening for Genital Herpes Simplex: Appendix 2. Quality Ratings for Studies on Antiviral Therapy

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Appendix 2. Quality Ratings for Studies on Antiviral Therapy

Study/Year	Random Assignment?	Allocation Concealed?	Groups Similar at Baseline?	Eligibility Criteria Specified?	Blinding: Outcome Assessors, Care Provider, Patient?	Intention- to-Treat Analysis?	Maintenance of Comparable Groups?	Reporting of Attrition, Contamination, etc.?	Differential Loss to Followup or Overall High Loss to Followup?	Quality Rating	External Validity
Adults and Adolescents
Corey,³³ 2004	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Good	International, multisite
Diaz-Mitoma,²⁸ 1998	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Good	Multisite
Reitano,³⁰ 1998	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Good	International, multisite
Patel,³¹ 1997	Yes	Yes	Yes	Yes	Yes	Yes	Yes	NR	NR	Fair	International, multisite
Mertz,²⁹ 1997	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Good	Multisite
Wald,³² 1996	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Good	Single research clinic site
Pregnant Women
Watts,⁴² 2003	Yes	Yes	Yes	Yes	Yes	NR	Yes	Yes	No	Good	Recruited from community
Scott,⁴³ 2002	Yes	Yes	Yes	Yes	Yes	Yes	Yes	NR	NR	Fair	Prenatal clinic, Texas
Braig,⁴⁶ 2001	No	No	Yes	Yes	No	No	NR	NR	Yes	Poor	French maternity ward
Scott,⁴⁷ 2001	No	No	No	Yes	No	Yes	No	Yes	NR	Poor	Prenatal clinic, Texas
Brocklehurst,⁴⁴ 1998	Yes	Yes	No	Yes	No	Yes	NR	No	NR	Poor	England, 2 clinic sites
Scott,⁴⁴ 1996	Yes	Yes	Yes	Yes	Yes	No	NR	Yes	NR	Poor	Texas hospital and clinic
Note: NR, not reported.