Figure. Screening for Genital Herpes: Analytic Framework and Key Questions

[D] Select for Text Description.

HSV, herpes simplex virus.
*Includes disseminated disease, encephalitis, neurological impairment, and death.

Key Questions

KQ 1a. Does screening for HSV in asymptomatic adolescents and adults reduce symptomatic recurrences and transmission of disease?
KQ 1b. Does screening for HSV in pregnant women reduce neonatal HSV and complications?
KQ 2. Can risk factors identify groups at higher risk for HSV infection?
KQ 3a. What are the HSV screening tests and their performance characteristics?
KQ 3b. What is the optimal time to screen during pregnancy?
KQ 3c. What is the role of screening partners?
KQ 4. What are the harms of screening?
KQ 5a. How effective are interventions in reducing symptomatic recurrences and transmission in adolescents and adults?
KQ 5b. How effective are interventions in reducing neonatal infection and complications?
KQ 6. What are the harms of interventions?

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